BDBM570909 US11440904, Compound 7

SMILES C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4OCCOCCOCCOc4c3)nc3[nH]cnc23)c1

InChI Key InChIKey=IZLUBQPWEKVIDI-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 570909   

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 0.410nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 0.410nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 0.650nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 0.650nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 0.650nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 1.35nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 1.35nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 208nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 208nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 208nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 274nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 274nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 274nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 324nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 675nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570909(US11440904, Compound 7)
Affinity DataIC50: 675nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent