BDBM571537 (rac)-18-chloro-1-ethyl-2-methyl-15-[3-(1-naphthyloxy)propyl]-2,3b,4,5,6,7,9,10,11,12-decahydropyrazolo[3′,4′:8,9]pyrido[1′,2′:6,7][1,6]diazacycloundecino[10,11,1-hi]indole-14-carboxylic Acid (Isomer 1)::US11440923, Example 102::US11440923, Example 103

SMILES CCc1c-2c(nn1C)C1CCCCN1CCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13

InChI Key InChIKey=AOBVUBMWZIKPMN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571537   

LigandPNGBDBM571537((rac)-18-chloro-1-ethyl-2-methyl-15-[3-(1-naphthyl...)
Affinity DataIC50: 0.940nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandPNGBDBM571537((rac)-18-chloro-1-ethyl-2-methyl-15-[3-(1-naphthyl...)
Affinity DataIC50: 1.40nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent