BDBM573964 2-amino-9-[(5S,7R,8R,12aR,14R,15aS)-14-(4- aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-2,10- dioxido-2,10-disulfanyloctahydro-12H-5,8- methanofuro[3,2-l][1,3,6,9,11,2,10] pentaoxadiphosphacyclotetradecin-7-yl]-1,9- dihydro-6H-purin-6-one (Diastereomer 1)::US11453697, Example 149::US11453697, Example 150::US11453697, Example 152

SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H]2C[C@H]1OP(S)(=O)OC[C@H]1O[C@H](C[C@@H]1OP(S)(=O)OC2)c1cnc2c(N)ncnn12

InChI Key InChIKey=CECDHZWLARQXCJ-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 573964   

LigandPNGBDBM573964(US11453697, Example 149 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandPNGBDBM573964(US11453697, Example 149 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573964(US11453697, Example 149 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50:  5.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

LigandPNGBDBM573964(US11453697, Example 149 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50:  8.40nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573964(US11453697, Example 149 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50:  111nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent