BDBM574712 (Free Acid): 3-(6-Aminopyridin-3-yl)-1-sulfamoyl-1H-pyrrole-2-carboxylic acid::US11459296, Example 1

SMILES Nc1ccc(cn1)-c1ccn(c1C(O)=O)S(N)(=O)=O

InChI Key InChIKey=AAGODIRAFGAKHV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 574712   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Infex Therapeutics

US Patent
LigandPNGBDBM574712(US11459296, Example 1 | (Free Acid): 3-(6-Aminopyr...)
Affinity DataIC50: 826nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Infex Therapeutics

US Patent
LigandPNGBDBM574712(US11459296, Example 1 | (Free Acid): 3-(6-Aminopyr...)
Affinity DataIC50: 830nMAssay Description:Inhibition of His-tagged bacterial NDM-1 (unknown origin) expressed in Escherichia coli BL21 star cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa)
University Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM574712(US11459296, Example 1 | (Free Acid): 3-(6-Aminopyr...)
Affinity DataIC50: 3.24E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant Pseudomonas aeruginosa Metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21 star cells usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed