BDBM575876 US11466016, Example 6::endo-9-[7-(4- chloro-2- methyl-2H- indazol-5-yl)- 5H-pyrrolo[2,3- b]pyrazin-3-yl]- 9-azabicyclo [3.3.1]nonan- 3-amine

SMILES Cn1cc2c(Cl)c(-c3c[nH]c4nc(N5[C@@H]6CCC[C@H]5C[C@@H](N)C6)cnc34)ccc2n1

InChI Key InChIKey=BBRSAKFBPPNJMB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575876   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 575876BDBM575876(US11466016, Example 6 | endo-9-[7-(4- chloro-2- me...)
Affinity DataIC50: 9nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent