BDBM575942 US11466016, Example 70::endo-8-(7-{4-chloro-2- [(1-methyl-1H-pyrazol- 3-yl)methyl]-2H- indazol-5- yl}-5H-pyrrolo[2,3- b]pyrazin-3-yl)-8- azabicyclo[3.2.1]octan- 3-amine, trihydrochloride salt

SMILES Cn1ccc(Cn2cc3c(Cl)c(-c4c[nH]c5nc(N6[C@H]7CC[C@H]6CC(N)C7)cnc45)ccc3n2)n1

InChI Key InChIKey=RWBZJLRILFSCBU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575942   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 575942BDBM575942(US11466016, Example 70 | endo-8-(7-{4-chloro-2- [(...)
Affinity DataIC50: 8.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent