BDBM575950 US11466016, Example 79::{6-[(1R,2S,3S,5S)-3- amino-2-fluoro-8- azabicyclo[3.2.1]octan-8- yl]-3-(4-chloro-2-methyl- 2H-indazol-5-yl)-1H- pyrazolo[3,4-b]pyrazin-5- yl}methanol

SMILES Cn1cc2c(Cl)c(-c3n[nH]c4nc(N5[C@H]6CC[C@H]5[C@@H](F)[C@@H](N)C6)c(CO)nc34)ccc2n1

InChI Key InChIKey=OYCTYGRYBSMUGZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575950   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 575950BDBM575950(US11466016, Example 79 | {6-[(1R,2S,3S,5S)-3- amin...)
Affinity DataIC50: 9.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent