BDBM575961 (1R,2S,3S,5S)-8-[3-(4- Chloro-2-ethyl-2H-indazol- 5-yl)-5-methyl-1H-pyraz- olo[3,4-b]pyrazin-6-yl]- 2-fluoro-8-aza- bicyclo[3.2.1]octan-3- amine::US11466016, Example 92

SMILES CCn1cc2c(Cl)c(-c3n[nH]c4nc(N5[C@@H]6CC[C@H]5[C@@H](F)[C@@H](N)C6)c(C)nc34)ccc2n1

InChI Key InChIKey=RNPSGOWCTZLYNP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575961   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 575961BDBM575961(US11466016, Example 92 | (1R,2S,3S,5S)-8-[3-(4- Ch...)
Affinity DataIC50: 8.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent