BDBM575965 7-{6-[(1R,2S,3S,5S)- 3-amino-2-fluoro-8- azabicyclo[3.2.1]octan- 8-yl]-5-methyl-1H- pyrazolo[3,4-b]pyrazin- 3-yl}-8-chloro-N,N- dimethylquinoxalin-2- amine::US11466016, Example 96

SMILES Cc1nc2c(-c3ccc4ncc(N(C)C)nc4c3Cl)n[nH]c2nc1N1[C@@H]2CC[C@H]1[C@@H](F)[C@@H](N)C2

InChI Key InChIKey=DNRZIJRKLANKIX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575965   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 575965BDBM575965(US11466016, Example 96 | 7-{6-[(1R,2S,3S,5S)- 3-am...)
Affinity DataIC50: 4.70nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent