BDBM575975 US11466016, Example 108::{6-[(1R,2S,3S,5S)- 3-amino-2-fluoro-8- azabicyclo[3.2.1]oc- tan-8-yl]-3-(3- chloro-2,4-dimeth- yl-2H-indazol-5- yl)-1H-pyrazolo [3,4-b]pyrazin- 5-yl}methanol

SMILES Cc1c(-c2n[nH]c3nc(N4[C@@H]5CC[C@H]4[C@@H](F)[C@@H](N)C5)c(CO)nc23)ccc2nn(C)c(Cl)c12

InChI Key InChIKey=IQIQNBBQLBEFAL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575975   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 575975BDBM575975(US11466016, Example 108 | {6-[(1R,2S,3S,5S)- 3-ami...)
Affinity DataIC50: 6.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
12/11/2022
Entry Details
US Patent