BDBM576414 7-(3,5-dimethyl-1 H-pyrazol-4-yl)[1,3]thiazolo[5,4-b]pyridine::WO2022112919, Example 19

SMILES Cc1n[nH]c(C)c1-c1ccnc2scnc12

InChI Key InChIKey=DTACCFWYCCCLSC-UHFFFAOYSA-N

Data  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 576414   

TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576414(7-(3,5-dimethyl-1 H-pyrazol-4-yl)[1,3]thiazolo[5,4...)
Affinity DataKd:  39nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576414(7-(3,5-dimethyl-1 H-pyrazol-4-yl)[1,3]thiazolo[5,4...)
Affinity DataEC50:  165nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed