BDBM576672 US11472791, Example 3

SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc(c(n1)-c1cnn(c1)C1CCOCC1)C(F)(F)F

InChI Key InChIKey=AZIPKRAMGTUALB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 576672   

LigandPNGBDBM576672(US11472791, Example 3)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of N-terminal GST-tagged full-length human CDK2(1 to 298 residues) /FLAG-tagged human Cyclin E1 (1 to 410 residues) expressed in baculovir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM576672(US11472791, Example 3)
Affinity DataIC50: 50nMAssay Description:CDK2/Cyclin E1 enzyme activity assays utilize full-length human CDK2 co-expressed as N-terminal GST-tagged protein with FLAG-Cyclin E1 in a baculovir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
US Patent

LigandPNGBDBM576672(US11472791, Example 3)
Affinity DataIC50: 407nMAssay Description:Inhibition of N-terminal GST-tagged full length human CDK1 (1 to 297 residues)/human Cyclin B1 (1 to 433 residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM576672(US11472791, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 90 mins in presence of ATP by fluorescence microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed