BDBM576679 US11472791, Example 10
SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc(c(n1)-c1cnn(CC(F)(F)F)c1)C(F)(F)F
InChI Key InChIKey=ZORUMGHLMKWRPP-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 576679
Affinity DataIC50: 1.80nMAssay Description:Inhibition of N-terminal GST-tagged full-length human CDK2(1 to 298 residues) /FLAG-tagged human Cyclin E1 (1 to 410 residues) expressed in baculovir...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal GST-tagged human CDK4 (4 to 303 residues)/N-terminal GST-tagged human Cyclin D1 (4 to 295 residues) expressed in Sf9 insect ...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of N-terminal GST-tagged human CDK6 (1 to 326 residues)/N-terminal 6-His fused human Cyclin D3 (1 to 292 residues) expressed in Sf9 insect...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:CDK2/Cyclin E1 enzyme activity assays utilize full-length human CDK2 co-expressed as N-terminal GST-tagged protein with FLAG-Cyclin E1 in a baculovir...More data for this Ligand-Target Pair
Affinity DataIC50: 205nMAssay Description:Inhibition of N-terminal GST-tagged full length human CDK1 (1 to 297 residues)/human Cyclin B1 (1 to 433 residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
Affinity DataIC50: 709nMAssay Description:Inhibition of CDK2 in human whole blood spiked with CCNE1-amplified human COV318 cells assessed as reduction in retinoblastoma protein phosphorylatio...More data for this Ligand-Target Pair