BDBM576727 2-Methyl-1-(4-(2-((1- (methylsulfonyl)piperidin- 4-yl)amino)-5- (trifluoromethyl)pyrimidin- 4-yl)-1H-pyrazol-1- yl)propan-2-ol::US11472791, Example 52
SMILES CC(C)(O)Cn1cc(cn1)-c1nc(NC2CCN(CC2)S(C)(=O)=O)ncc1C(F)(F)F
InChI Key InChIKey=KSGRHPFFOUUFPR-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 576727
Affinity DataIC50: 0.420nMAssay Description:Inhibition of N-terminal GST-tagged full-length human CDK2(1 to 298 residues) /FLAG-tagged human Cyclin E1 (1 to 410 residues) expressed in baculovir...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of N-terminal GST-tagged human CDK4 (4 to 303 residues)/N-terminal GST-tagged human Cyclin D1 (4 to 295 residues) expressed in Sf9 insect ...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:CDK2/Cyclin E1 enzyme activity assays utilize full-length human CDK2 co-expressed as N-terminal GST-tagged protein with FLAG-Cyclin E1 in a baculovir...More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of N-terminal GST-tagged full length human CDK1 (1 to 297 residues)/human Cyclin B1 (1 to 433 residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of N-terminal GST-tagged human CDK6 (1 to 326 residues)/N-terminal 6-His fused human Cyclin D3 (1 to 292 residues) expressed in Sf9 insect...More data for this Ligand-Target Pair
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of CDK2 in human whole blood spiked with CCNE1-amplified human COV318 cells assessed as reduction in retinoblastoma protein phosphorylatio...More data for this Ligand-Target Pair