BDBM576729 2-((1- (Cyclopropylsulfonyl) piperidin-4-yl)amino)-4-(1- (2-hydroxy-2- methylpropyl)-1H- pyrazol-4-yl)pyrimidine- 5-carbonitrile::US11472791, Example 54
SMILES CC(C)(O)Cn1cc(cn1)-c1nc(NC2CCN(CC2)S(=O)(=O)C2CC2)ncc1C#N
InChI Key InChIKey=GGTPTLANFCGFPU-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 576729
Affinity DataIC50: 0.650nMAssay Description:Inhibition of N-terminal GST-tagged full-length human CDK2(1 to 298 residues) /FLAG-tagged human Cyclin E1 (1 to 410 residues) expressed in baculovir...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of N-terminal GST-tagged human CDK4 (4 to 303 residues)/N-terminal GST-tagged human Cyclin D1 (4 to 295 residues) expressed in Sf9 insect ...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:CDK2/Cyclin E1 enzyme activity assays utilize full-length human CDK2 co-expressed as N-terminal GST-tagged protein with FLAG-Cyclin E1 in a baculovir...More data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of CDK2 in CCNE1-amplified human COV318 cells assessed as reduction in retinoblastoma protein phosphorylation at S780 residue incubated ov...More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of N-terminal GST-tagged human CDK6 (1 to 326 residues)/N-terminal 6-His fused human Cyclin D3 (1 to 292 residues) expressed in Sf9 insect...More data for this Ligand-Target Pair
Affinity DataIC50: 126nMAssay Description:Inhibition of N-terminal GST-tagged full length human CDK1 (1 to 297 residues)/human Cyclin B1 (1 to 433 residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
Affinity DataIC50: 146nMAssay Description:Inhibition of CDK2 in human whole blood spiked with CCNE1-amplified human COV318 cells assessed as reduction in retinoblastoma protein phosphorylatio...More data for this Ligand-Target Pair
Affinity DataIC50: 375nMAssay Description:Inhibition of CDK1 in human OVCAR-3 cells assessed as reduction in nucleophosmin phosphorylation at T199 residue incubated for 30 mins by In-cell wes...More data for this Ligand-Target Pair
Affinity DataIC50: 2.64E+3nMAssay Description:Inhibition of N-terminal GST-tagged full length human CDK9 (1 to 372 residues)/His-tagged human Cyclin T1 (1 to 726 residues) expressed in baculoviru...More data for this Ligand-Target Pair
Affinity DataIC50: 3.82E+3nMAssay Description:Inhibition of C-terminal 6-His tagged recombinant full-length human CDK7/recombinant full-length human Cyclin H/N-terminal GST-tagged recombinant ful...More data for this Ligand-Target Pair