BDBM577717 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2-methyl-12-(2,2,3,3-tetrafluoropropyl)-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,4]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 123

SMILES CCc1c-2c(CCCN(CC(F)(F)C(F)F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C

InChI Key InChIKey=DRNIXHSDQJHFDF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 577717   

LigandPNGBDBM577717((rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)...)
Affinity DataIC50:  5.60nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM577717((rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)...)
Affinity DataIC50:  1.90E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetBcl-2-like protein 1 [1-212]/Bad BH3 Peptide(Human)
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US Patent
LigandPNGBDBM577717((rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)...)
Affinity DataIC50: >2.00E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-XL and the BH3 domain of Bad (both human) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent