BDBM577720 (rac)-4-Chloro-3-ethyl-12,12-difluoro-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indol-14-ium-8-carboxylate::US11478451, Example 126::US11478451, Example 127::US11478451, Example 128

SMILES CCc1c-2c(CN(C)CC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C

InChI Key InChIKey=YZYMZHBSKWEGRE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 577720   

LigandPNGBDBM577720(US11478451, Example 126 | (rac)-4-Chloro-3-ethyl-1...)
Affinity DataIC50: 1nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

LigandPNGBDBM577720(US11478451, Example 126 | (rac)-4-Chloro-3-ethyl-1...)
Affinity DataIC50: 1.20nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

LigandPNGBDBM577720(US11478451, Example 126 | (rac)-4-Chloro-3-ethyl-1...)
Affinity DataIC50: 15nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetBcl-2-like protein 1 [1-212]/Bad BH3 Peptide(Human)
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US Patent
LigandPNGBDBM577720(US11478451, Example 126 | (rac)-4-Chloro-3-ethyl-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-XL and the BH3 domain of Bad (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

LigandPNGBDBM577720(US11478451, Example 126 | (rac)-4-Chloro-3-ethyl-1...)
Affinity DataIC50: 2.00E+4nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent