BDBM578566 3-[3-(1- ethylpyrazol-4- yl)-5-fluoro-2- pyridyl]-3- methoxy-5,5- dimethyl-6-oxo- cyclohexene-1- carbonitrile (Enantiomer A)::US11479539, Compound 181::US11479539, Compound 86

SMILES CCn1cc(cn1)-c1cc(F)cnc1C1(CC(C)(C)C(=O)C(=C1)C#N)OC

InChI Key InChIKey=AUWVZLMIZSBHSJ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 578566   

Targethek293 luciferase(HIV-1)
Medimmune

US Patent
LigandPNGBDBM578566(US11479539, Compound 86 | 3-[3-(1- ethylpyrazol-4-...)
Affinity DataEC50:  9nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

Targethek293 luciferase(HIV-1)
Medimmune

US Patent
LigandPNGBDBM578566(US11479539, Compound 86 | 3-[3-(1- ethylpyrazol-4-...)
Affinity DataEC50:  68nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent