BDBM579943 3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl 3,4-dihydroisoquinoline-2(1H)-carboxylate (Prepared according to Scheme 4)::US11485731, Example 3A

SMILES OC(COC(=O)N1CCc2ccccc2C1)CN1CCc2ccccc2C1

InChI Key InChIKey=NWCCQRMIKQRTFW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 579943   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM579943(US11485731, Example 3A | 3-(3,4-dihydroisoquinolin...)
Affinity DataIC50: 192nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the IC50 activity of PRMT5 of the compounds of Examples 1A to 7 above. Biotinylated histone peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent