BDBM581349 US11505523, Compound 22b

SMILES COc1ccc(\C=C\C(=O)NO)c(c1)-c1ccc(Br)cc1

InChI Key InChIKey=SUDOUVOSYKXTMX-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 581349   

TargetHistone deacetylase 1(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 4.5nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 3(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 4.80nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of HDAC8 (unknown origin) assessed as release of fluorogenic AMC pre-incubated for 15 mins followed by addition of trypsin and substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 5.70nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetPolyamine deacetylase HDAC10(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 4(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 2(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using Ac-Leu-Gly-Lys(Ac)-AMC as substrate pre-incubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of HDAC3 (unknown origin) assessed as release of fluorogenic AMC pre-incubated for 15 mins followed by addition of trypsin and substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC10 (unknown origin) assessed as release of fluorogenic AMC pre-incubated for 15 mins followed by addition of trypsin and substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
City of Hope

US Patent
LigandPNGBDBM581349(US11505523, Compound 22b)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC2 (unknown origin) assessed as release of fluorogenic AMC pre-incubated for 15 mins followed by addition of trypsin and substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed