BDBM581371 US11505527, Compound 4j

SMILES Cc1ccc(S(=O)(=O)c2ccc(C3C(C(=O)c4ccccc4)=C(N)NC4=C3C(=O)CC(C)(C)C4)cc2)cc1

InChI Key InChIKey=NNFDRCGXLJTASH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 581371   

TargetPlatelet-derived growth factor receptor beta(Human)
King Abdulaziz University

US Patent
LigandChemical structure of BindingDB Monomer ID 581371BDBM581371(US11505527, Compound 4j)
Affinity DataIC50: 0.140nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
King Abdulaziz University

US Patent
LigandChemical structure of BindingDB Monomer ID 581371BDBM581371(US11505527, Compound 4j)
Affinity DataIC50: 0.140nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
King Abdulaziz University

US Patent
LigandChemical structure of BindingDB Monomer ID 581371BDBM581371(US11505527, Compound 4j)
Affinity DataIC50: 0.340nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
King Abdulaziz University

US Patent
LigandChemical structure of BindingDB Monomer ID 581371BDBM581371(US11505527, Compound 4j)
Affinity DataIC50: 0.600nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent