BDBM581783 US11512080, Compound I-107

SMILES O=C1CCC(SCc2ccccc2)C(=O)N1

InChI Key InChIKey=QWOOTRSQFSTMBW-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 581783   

TargetProtein cereblon(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM581783(US11512080, Compound I-107)
Affinity DataKi:  2.00E+4nMAssay Description:Binding affinity to human CRBN thalidomide binding domain assessed as inhibition constant by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM581783(US11512080, Compound I-107)
Affinity DataIC50: 5.50E+4nMAssay Description:Equal volumes of His-tagged CRBN-DDB1 complex (56 nM) was mixed with Eu-cryptate labeled Anti-6HIS-monoclonal antibody (50× dilution from the commerc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent