BDBM586397 US11530244, Compound 122

SMILES C[C@@]12CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1c3ccccc3C(=N[C@@H](NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CCSCc3cccc(CSC[C@H](NC2=O)C(N)=O)c3)C1=O)c1ccccc1

InChI Key InChIKey=OUHIHZKBZJHMKN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 586397   

LigandPNGBDBM586397(US11530244, Compound 122)
Affinity DataIC50: 50nMAssay Description:The PCSK9 Alexa FRET Plus assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent B (KD=35 nM). A solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM586397(US11530244, Compound 122)
Affinity DataIC50: 50nMAssay Description:The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent