BDBM587667 5-(2-tert-butoxy-3-pyridyl)-1-isopropyl-N- [(3R)-tetrahydrofuran-3-yl]pyrazolo[4,3- b]pyridin-7-amine::US11535611, Example 36

SMILES CC(C)n1ncc2nc(cc(N[C@@H]3CCOC3)c12)-c1cccnc1OC(C)(C)C

InChI Key InChIKey=ONUWUZXNTMRHEG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 587667   

LigandPNGBDBM587667(5-(2-tert-butoxy-3-pyridyl)-1-isopropyl-N- [(3R)-t...)
Affinity DataIC50: 91nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

LigandPNGBDBM587667(5-(2-tert-butoxy-3-pyridyl)-1-isopropyl-N- [(3R)-t...)
Affinity DataIC50: 260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

LigandPNGBDBM587667(5-(2-tert-butoxy-3-pyridyl)-1-isopropyl-N- [(3R)-t...)
Affinity DataIC50: 3.23E+3nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent