BDBM589168 US11548903, Example 101

SMILES NC1=N[C@@]2(c3cc(/C=C(\F)c4ccc(Cl)cn4)ccc3F)CN(c3ncc(F)cn3)C[C@H]2CS1

InChI Key InChIKey=QWWBKEHWUIMNGN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 589168   

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 589168BDBM589168(US11548903, Example 101)
Affinity DataIC50: 1.03nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 589168BDBM589168(US11548903, Example 101)
Affinity DataIC50: 1.84nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 589168BDBM589168(US11548903, Example 101)
Affinity DataIC50: 4.91E+4nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent