BDBM589210 US11548903, Example 138

SMILES Cc1cc(C#N)cnc1/C(F)=C/c1ccc(F)c([C@]23CO[C@H](C(F)(F)F)[C@H]2CSC(N)=N3)c1

InChI Key InChIKey=GRUTXYOBHJITRJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 589210   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 589210BDBM589210(US11548903, Example 138)
Affinity DataIC50: 27.2nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 589210BDBM589210(US11548903, Example 138)
Affinity DataIC50: 1.14E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 589210BDBM589210(US11548903, Example 138)
Affinity DataIC50: 4.00E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent