BDBM590754 US11564920, Example 29

SMILES COc1cncc(OC[C@@H](F)CN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1

InChI Key InChIKey=IJXJFPUMWILOPF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 590754   

TargetSerine/threonine-protein kinase Chk1(Human)
Sumitomo Pharma Co., Ltd.

US Patent
LigandChemical structure of BindingDB Monomer ID 590754BDBM590754(US11564920, Example 29 | US20250352541, Example 29)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2026
Entry Details US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sumitomo Pharma Co., Ltd.

US Patent
LigandChemical structure of BindingDB Monomer ID 590754BDBM590754(US11564920, Example 29 | US20250352541, Example 29)
Affinity DataIC50: 1.12E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2026
Entry Details US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sumitomo Pharma Co., Ltd.

US Patent
LigandChemical structure of BindingDB Monomer ID 590754BDBM590754(US11564920, Example 29 | US20250352541, Example 29)
Affinity DataIC50: 1.12E+4nMAssay Description:The test compounds were added to cultured hERG (human Ether-a-go-go Related Gene) gene stably expressing CHO cell line cells to achieve 0.27 to 100 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent