BDBM591102 (2R)-2-(4-(8-amino-7-fluoro-6-(4-methylpyridin-3-yl)isoquinolin-3-ylamino)-1H-pyrazol-1-yl)propanenitrile::US11566003, Compound 194

SMILES C[C@@H](C#N)n1cc(Nc2cc3cc(c(F)c(N)c3cn2)-c2cnccc2C)cn1

InChI Key InChIKey=OLQCQJDTGHVLDC-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 591102   

LigandChemical structure of BindingDB Monomer ID 591102BDBM591102((2R)-2-(4-(8-amino-7-fluoro-6-(4-methylpyridin-3-y...)
Affinity DataKi:  0.790nMAssay Description:For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 591102BDBM591102((2R)-2-(4-(8-amino-7-fluoro-6-(4-methylpyridin-3-y...)
Affinity DataEC50:  419nMAssay Description:Inhibition of HPK1 in primary human Pan T cells assessed as increase in IL-2 secretion pretreated for 30 mins followed by incubation with anti-CD3/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 591102BDBM591102((2R)-2-(4-(8-amino-7-fluoro-6-(4-methylpyridin-3-y...)
Affinity DataIC50: 570nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of anti-CD3/anti-CD28-induced SLP76 phosporylation at Ser376 residue incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed