BDBM5919 3-[4-(7-methoxy-1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]-1-(3-methylphenyl)urea::CHEMBL184223::isoindolinone analog 26

SMILES COc1ccc(c2CNC(=O)c12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1

InChI Key InChIKey=XZXIHTJGNYBSTH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5919   

TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5919(3-[4-(7-methoxy-1-oxo-2,3-dihydro-1H-isoindol-4-yl...)
Affinity DataIC50: 21nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5919(3-[4-(7-methoxy-1-oxo-2,3-dihydro-1H-isoindol-4-yl...)
Affinity DataIC50: 21nMpH: 7.4 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2005
Entry Details Article
PubMed