BDBM594299 US11584747, Example 93::US11584747, Example 94::US11584747, Example 95

SMILES CC[C@@H]1CN([C@@H](C)CN1C(c1ccc(OC(F)(F)F)cc1)c1ccccn1)c1nc(=O)n(C)c2ccc(nc12)C#N

InChI Key InChIKey=XSORAHGOFUGSSD-ZSFYKYPJSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 594299   

TargetDiacylglycerol kinase alpha [9-727](Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594299(US11584747, Example 93 | US11584747, Example 94 | ...)
Affinity DataIC50:  18nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase zeta(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594299(US11584747, Example 93 | US11584747, Example 94 | ...)
Affinity DataIC50:  520nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase alpha(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594299(US11584747, Example 93 | US11584747, Example 94 | ...)
Affinity DataIC50:  200nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase zeta(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594299(US11584747, Example 93 | US11584747, Example 94 | ...)
Affinity DataIC50:  290nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase zeta(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594299(US11584747, Example 93 | US11584747, Example 94 | ...)
Affinity DataIC50:  86nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase alpha(Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594299(US11584747, Example 93 | US11584747, Example 94 | ...)
Affinity DataIC50:  150nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase alpha [9-727](Homo sapiens)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594299(US11584747, Example 93 | US11584747, Example 94 | ...)
Affinity DataIC50:  16nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent