BDBM594331 US11584747, Example 126::US11584747, Example 127::US20240108654, Compound 27

SMILES C[C@@H]1CN([C@@H](C)CN1C(c1ccc(F)cc1)c1ccc(cn1)C(F)(F)F)c1nc(=O)n(C)c2ccc(nc12)C#N

InChI Key InChIKey=XNOWKAWYXXGCHS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 594331   

TargetDiacylglycerol kinase alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594331(US11584747, Example 126 | US11584747, Example 127 ...)
Affinity DataIC50: 180nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDiacylglycerol kinase alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594331(US11584747, Example 126 | US11584747, Example 127 ...)
Affinity DataIC50: 190nMAssay Description:The DGKα and DGKζ reactions were performed using either extruded liposome (DGKα and DGKζ LIPGLO assays) or detergent/lipid micell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetDiacylglycerol kinase alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594331(US11584747, Example 126 | US11584747, Example 127 ...)
Affinity DataIC50: 190nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Juno Therapeutics

US Patent
LigandPNGBDBM594331(US11584747, Example 126 | US11584747, Example 127 ...)
Affinity DataIC50: 440nMAssay Description:The DGKα and DGKζ reactions were performed using either extruded liposome (DGKα and DGKζ LIPGLO assays) or detergent/lipid micell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Juno Therapeutics

US Patent
LigandPNGBDBM594331(US11584747, Example 126 | US11584747, Example 127 ...)
Affinity DataIC50: 440nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Juno Therapeutics

US Patent
LigandPNGBDBM594331(US11584747, Example 126 | US11584747, Example 127 ...)
Affinity DataIC50: 560nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent