BDBM594441 US11584747, Example 243::US20240108654, Compound 31

SMILES CCCC(N1C[C@H](CC)N(C[C@H]1CC)c1nc(=O)n(C)c2ccc(nc12)C#N)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=RYANVYSVCYNQFK-AXWGZAFASA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 594441   

TargetDiacylglycerol kinase alpha [9-727](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594441(US11584747, Example 243 | US20240108654, Compound ...)
Affinity DataIC50:  6nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol kinase zeta(Human)
Juno Therapeutics

US Patent
LigandPNGBDBM594441(US11584747, Example 243 | US20240108654, Compound ...)
Affinity DataIC50:  39nMAssay Description:The DGKα and DGKζ reactions were performed using either extruded liposome (DGKα and DGKζ LIPGLO assays) or detergent/lipid micell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDiacylglycerol kinase zeta(Human)
Juno Therapeutics

US Patent
LigandPNGBDBM594441(US11584747, Example 243 | US20240108654, Compound ...)
Affinity DataIC50:  39nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent