BDBM595574 4-(((5′-chloro-2′-(((1R,4r)-4-(((R)-1-((2-methyl-2H-tetrazol-5-yl)methoxy)propan-2-yl)amino)cyclohexyl)amino)-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (Compound 33) and 4-(((5′-chloro-2′-(((1S,4r)-4-(((S)-1-((2-methyl-2H-tetrazol-5-yl)methoxy)propan-2-yl)amino)cyclohexyl)amino)-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile ::US11591322, Compound 34

SMILES C[C@@H](COCc1nnn(C)n1)N[C@H]1CC[C@H](Nc2cc(-c3cccc(NCC4(C#N)CCOCC4)n3)c(Cl)cn2)CC1

InChI Key InChIKey=BGJDLKTYVVXXRM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 595574   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Algen Biotechnologies

US Patent
LigandChemical structure of BindingDB Monomer ID 595574BDBM595574(US11591322, Compound 34 | 4-(((5′-chloro-2&#...)
Affinity DataIC50: 10nMAssay Description:To each well of a 96-well plate was added 5× kinase assay buffer with 10 mM DTT (6 μL), 500 μM ATP (1 μL), 5×CDK substrate (10 μL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent