BDBM597349 ((5R,9S)-2-Methyl-3-(3,4,5-trifluorophenyl)-4,5,6,7,8,9-hexahydro- 2H-5,9-epiminocycloocta[c]pyrazol-10-yl)(pyrrolo[1,2-a]pyrazin-8- yl)methanone;::US11597728, Example 236

SMILES Cn1nc2[C@H]3CCC[C@@H](Cc2c1-c1cc(F)c(F)c(F)c1)N3C(=O)c1ccn2ccncc12

InChI Key InChIKey=LFPYOYCEWZUESX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 597349   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM597349(((5R,9S)-2-Methyl-3-(3,4,5-trifluorophenyl)-4,5,6,...)
Affinity DataIC50: 1.26nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
US Patent