BDBM597476 ((5R,9S)-2-Methyl-3-(3,4,5-trifluorophenyl)-4,5,6,7,8,9-hexahydro- 2H-5,9-epiminocycloocta[c]pyrazol-10-yl)(2-methylimidazo[1,2- b]pyridazin-3-yl)methanone;::US11597728, Example 363

SMILES Cc1nc2cccnn2c1C(=O)N1[C@H]2CCC[C@@H]1c1nn(C)c(c1C2)-c1cc(F)c(F)c(F)c1

InChI Key InChIKey=FHFOYCHYVWPOQS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 597476   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM597476(((5R,9S)-2-Methyl-3-(3,4,5-trifluorophenyl)-4,5,6,...)
Affinity DataIC50: 1.61nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
US Patent