BDBM597561 US11597733, Example 4-13

SMILES COc1nc(C)ccc1-c1cnc2sc(nn12)N1CCC(O)(CN)CC1

InChI Key InChIKey=MIYJPKCVTQPVFU-UHFFFAOYSA-N

Data  1 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 597561   

TargetSerine/threonine-protein kinase pim-1(Human)
Novartis

US Patent
LigandPNGBDBM597561(US11597733, Example 4-13)
Affinity DataKd: >100nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
US Patent

LigandPNGBDBM597561(US11597733, Example 4-13)
Affinity DataKd: >100nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Novartis

US Patent
LigandPNGBDBM597561(US11597733, Example 4-13)
Affinity DataKd: >100nMAssay Description:Binding reactions were assembled by combining kinases, liganded affinity beads, and test compounds in 1× binding buffer (20% SeaBlock, 0.17×PBS, 0.05...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM597561(US11597733, Example 4-13)
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibition of hERG by Qpatch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed