BDBM597946 (4-chloro-3-methyl- [1,2]oxazolo[5,4-b]pyridin-5- yl)-[rac-(7R,9aR)-7-(3- chloro-4-fluorophenyl)- 1,3,4,6,7,8,9,9a- octahydropyrido[1,2- a]pyrazin-2-yl]methanone::US11608347, Example 64::US11608347, Example 64-A

SMILES Cc1noc2ncc(C(=O)N3CCN4C[C@H](CC[C@@H]4C3)c3ccc(F)c(Cl)c3)c(Cl)c12

InChI Key InChIKey=GNPXLNOTNGBNTB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 597946   

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597946(US11608347, Example 64 | US11608347, Example 64-A ...)
Affinity DataIC50: 39.3nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM597946(US11608347, Example 64 | US11608347, Example 64-A ...)
Affinity DataIC50: 58nMAssay Description:In one embodiment, the present invention provides compounds of formula (Ie) and their pharmaceutically acceptable salts as described herein, wherein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
US Patent