BDBM598085 (cis)-4-Methyltetrahydrofuran-3-yl(8-::US11612606, Compound 441c

SMILES C[C@H]1COC[C@@H]1OC(=O)Nc1cc2cc(c(F)c(N)c2cn1)-c1cnc2OCCNc2c1C

InChI Key InChIKey=ABFKLHVMHUGOBS-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 598085   

LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataKi:  0.160nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 0.720nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Genentech Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 2.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetMisshapen-like kinase 1(Human)
Genentech Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 3.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataEC50:  6.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 31nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 44nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAurora kinase B(Human)
Genentech Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Genentech Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed