BDBM599942 3-{4-amino-5-[(3,3-difluoroazetidin-1- yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-7- yl}-N-[(3R,4S)-1-(3,3- difluorocyclopentanecarbonyl)-4- fluoropyrrolidin-3-yl]benzamide::US11618753, Example 1178

SMILES Nc1ncnn2c(cc(CN3CC(F)(F)C3)c12)-c1cccc(c1)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCC(F)(F)C1

InChI Key InChIKey=UDVZCCNJGINRPH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 599942   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM599942(US11618753, Example 1178 | 3-{4-amino-5-[(3,3-difl...)
Affinity DataIC50: 2.20E+3nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2023
Entry Details
US Patent