BDBM600730 US11629154, Example I-101

SMILES C[C@@H]1C[C@H]2OC(N)=N[C@](CF)(c3cc(NC(=O)c4ncc(C(F)(F)F)cc4Cl)ccc3F)[C@H]2CO1

InChI Key InChIKey=BERGZMIVUMKXAJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 600730   

TargetBeta-secretase 1(Human)
Shionogi

US Patent
LigandChemical structure of BindingDB Monomer ID 600730BDBM600730(US11629154, Example I-101)
Affinity DataIC50: 28.2nMAssay Description:To explore the BACE1 versus BACE2 enzyme selectivity, the binding affinity (Ki) to the respective purified enzymes was determined in a competitive ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Shionogi

US Patent
LigandChemical structure of BindingDB Monomer ID 600730BDBM600730(US11629154, Example I-101)
Affinity DataIC50: 398nMAssay Description:To explore the BACE1 versus BACE2 enzyme selectivity, the binding affinity (Ki) to the respective purified enzymes was determined in a competitive ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
US Patent