BDBM601960 8'-methyl-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 71::US20240150369, Compound 71

SMILES CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)C(=O)N4CCN(C)CC4)nc3n2C11CCCCC1

InChI Key InChIKey=QWDLZMUWYCLKFF-UHFFFAOYSA-N

Data  12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 601960   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
6/11/2023
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Date in BDB:
8/9/2024
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TargetCDK2/Cyclin-E2(Human)
Pharmacosmos Holding

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/9/2025
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TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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In Depth
Date in BDB:
6/11/2023
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TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
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TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
12/9/2025
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 9nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/9/2024
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 9nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
6/11/2023
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 9nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/9/2024
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 9nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
Entry Details
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 9nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
12/9/2025
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 9nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/9/2025
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TargetCyclin-dependent kinase 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 15nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
6/11/2023
Entry Details
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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 15nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
6/11/2023
Entry Details
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TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 15nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 15nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
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TargetCyclin-dependent kinase 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 15nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/9/2025
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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601960(US11643416, Compound 71 | 8'-methyl-2'-((4-(4- met...)Copy SMILESCopy InChI

Affinity DataIC50: 15nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/9/2025
Entry Details
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