BDBM602346 (R)-N-(1-(3-(1,1-difluoro-2-((1- isopropylazetidin- 3-yl)oxy)-2-methylpropyl)-2- fluorophenyl)ethyl)- 6-(4-isopropylpiperazin-1-yl)-7-methoxy- 2-methylpyrido[2,3-d]pyrimidin-4-amine::US11648254, Compound 242

SMILES COc1nc2nc(C)nc(N[C@H](C)c3cccc(c3F)C(F)(F)C(C)(C)OC3CN(C3)C(C)C)c2cc1N1CCN(CC1)C(C)C

InChI Key InChIKey=PMHHCXKEODPDNG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 602346   

TargetSon of sevenless homolog 1(Human)
Kumquat Biosciences

US Patent
LigandPNGBDBM602346(US11648254, Compound 242 | (R)-N-(1-(3-(1,1-difluo...)
Affinity DataIC50: 100nMAssay Description:The ability of any compound of the present disclosure to reduce a Ras protein signaling output by, e.g., interfering or disrupting interaction (or bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent