BDBM602709 2-[1-[2-Isoindolin-2-yl-4-oxo-6-(trifluoromethyl)chromen-8-yl]ethyl amino]benzoic acid::US11649227, Example 342::US20230286960, Example 342

SMILES C[C@H](Nc1ccccc1C(O)=O)c1cc(cc2c1oc(cc2=O)N1Cc2ccccc2C1)C(F)(F)F

InChI Key InChIKey=WLHDEXXHMSJPIO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 602709   

LigandPNGBDBM602709(US11649227, Example 342 | 2-[1-[2-Isoindolin-2-yl-...)
Affinity DataIC50: 500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

LigandPNGBDBM602709(US11649227, Example 342 | 2-[1-[2-Isoindolin-2-yl-...)
Affinity DataIC50: 500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

LigandPNGBDBM602709(US11649227, Example 342 | 2-[1-[2-Isoindolin-2-yl-...)
Affinity DataIC50: 500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

LigandPNGBDBM602709(US11649227, Example 342 | 2-[1-[2-Isoindolin-2-yl-...)
Affinity DataIC50: 500nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6× his tagged p110...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent