BDBM602730 (5Z)-5-[(1-phenylpyrazole-4-yl)methylene]-2-thioxo-thiazolidin-4-one::US11649231, Example 1-1::US11649231, Example 1-1K

SMILES O=C1NC(=S)S\C1=C/c1cnn(c1)-c1ccccc1

InChI Key InChIKey=DZBOJHSPQXHPEC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 602730   

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM602730((5Z)-5-[(1-phenylpyrazole-4-yl)methylene]-2-thioxo...)
Affinity DataIC50: 24nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetTarget of rapamycin complex subunit LST8(Human)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM602730((5Z)-5-[(1-phenylpyrazole-4-yl)methylene]-2-thioxo...)
Affinity DataIC50: 45nMAssay Description:Inhibition of mTORC1 in human SW620 cells assessed as measuring phosphorylated p70S6K level incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM602730((5Z)-5-[(1-phenylpyrazole-4-yl)methylene]-2-thioxo...)
Affinity DataIC50: 45nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent