BDBM603013 N-(3-(5-chloro-2- (difluoromethoxy)phenyl)-1H- pyrazol-4-yl)-1H-pyrazolo[4,3- c]pyridine-7-carboxamide::US11649241, Example 6

SMILES FC(F)Oc1ccc(Cl)cc1-c1n[nH]cc1NC(=O)c1cncc2cn[nH]c12

InChI Key InChIKey=JIRRPWVFUBYRKX-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 603013   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM603013(N-(3-(5-chloro-2- (difluoromethoxy)phenyl)-1H- pyr...)
Affinity DataKi:  0.480nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM603013(N-(3-(5-chloro-2- (difluoromethoxy)phenyl)-1H- pyr...)
Affinity DataKi:  7.35nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent