BDBM603018 N-(3-(5-chloro-2- (difluoromethoxy)phenyl)-1H- pyrazol-4-yl)furo[3,2-b]pyridine-3- carboxamide::US11649241, Example 11

SMILES FC(F)Oc1ccc(Cl)cc1-c1n[nH]cc1NC(=O)c1coc2cccnc12

InChI Key InChIKey=MXAVOGVTZLDXRR-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 603018   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM603018(N-(3-(5-chloro-2- (difluoromethoxy)phenyl)-1H- pyr...)
Affinity DataKi:  0.490nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM603018(N-(3-(5-chloro-2- (difluoromethoxy)phenyl)-1H- pyr...)
Affinity DataKi:  0.560nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent