BDBM603904 US11655239, Compound S18

SMILES CCC(NC(=O)c1ccc(C2CC2)c(c1)-c1ccc2nc(Nc3cnn(c3)C3CC3)ncc2c1)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=PZONUQMAOPGZCA-UHFFFAOYSA-N

Data  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 603904   

TargetDiscoidin domain-containing receptor 2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 0.200nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetEphrin-A2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase 11(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetALK tyrosine kinase receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 603904BDBM603904(US11655239, Compound S18)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzyme reaction substrate Poly(Glu, Tyr) 4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent