BDBM604270 US11661419, Example 19::US20230280220, Example 19

SMILES COc1cc2[nH]c(nc2cc1N(C)C(=O)[C@H](C)N1CCOCC1)-c1n[nH]c2C[C@@]3(C)C[C@H]3Cc12

InChI Key InChIKey=QQUUPGRGVHLEQQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 604270   

TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

US Patent
LigandPNGBDBM604270(US11661419, Example 19 | US20230280220, Example 19)
Affinity DataIC50: 9nMAssay Description:1.0M HEPES Buffer pH 7.5 solution was prepared as follows: 238.3 g HEPES free acid (Sigma) and 800 mL of water were combined, and the mixture was sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

US Patent
LigandPNGBDBM604270(US11661419, Example 19 | US20230280220, Example 19)
Affinity DataIC50: 9nMAssay Description:ITK activity was determined by measuring the effect of a test compound in an ITK enzyme assay. 1.0 M HEPES Buffer pH 7.5 solution was prepared as fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
US Patent