BDBM604295 US11661419, Example 44::US20230280220, Example 44

SMILES CCc1cc(cc2nc([nH]c12)-c1n[nH]c2C[C@@]3(C)C[C@H]3Cc12)N(C)C(=O)[C@H](C)N1CCOCC1

InChI Key InChIKey=QGFDYDICHZVLEO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 604295   

TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

US Patent
LigandPNGBDBM604295(US11661419, Example 44 | US20230280220, Example 44)
Affinity DataIC50: 28nMAssay Description:ITK activity was determined by measuring the effect of a test compound in an ITK enzyme assay. 1.0 M HEPES Buffer pH 7.5 solution was prepared as fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

US Patent
LigandPNGBDBM604295(US11661419, Example 44 | US20230280220, Example 44)
Affinity DataIC50: 28nMAssay Description:1.0M HEPES Buffer pH 7.5 solution was prepared as follows: 238.3 g HEPES free acid (Sigma) and 800 mL of water were combined, and the mixture was sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
US Patent