BDBM604928 N-(5-Cyano-4-(((3,4)-trans-4-methoxytetrahydro-2H-pyran-3-yl)oxy)pyridin-2-yl) -7-formyl-6-((3-carbonylmorpholino)methyl)-3,4-dihydro-1,8-naphthyridin-1(2H)-carboxamide::US11667631, Example 68::US11667631, Example 69

SMILES CO[C@H]1CCOCC1Oc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc23)ncc1C#N

InChI Key InChIKey=LLGZEQYMSQMRKL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 604928   

TargetFibroblast growth factor receptor 4(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM604928(US11667631, Example 68 | US11667631, Example 69 | ...)
Affinity DataIC50: 2.73nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR4 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM604928(US11667631, Example 68 | US11667631, Example 69 | ...)
Affinity DataIC50: 3.30nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR4 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM604928(US11667631, Example 68 | US11667631, Example 69 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR1 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM604928(US11667631, Example 68 | US11667631, Example 69 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR1 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
US Patent